The unique properties of Polyaphron Dispersions give rise to a
number of novel and unique delivery modalities:
ATDs are a class of alternative cream, lotions, spray, foams,
gels and droplets, based on Polyaphron Dispersions for topical
applications on the skin, the scalp and/or in the eyes.
TFE is a method by which we incorporate drug loaded Polyaphron
Dispersions into a wide selection of polymer film. The aphrons
containing the drug is released when the TFE is in contact with the
target tissue. The principal use of TFE is in the controlled
release of oil-soluble drugs.
TFE takes advantage of the fact that Polyaphron Dispersions are
extremely stable and resist the powerful forces generated in
film-forming polymers during the film-forming stage
(when conventional dispersions, such as emulsions, are ripped
apart).
TFE can be used for a number of applications including dermal
routes in the form of skin patches and wound dressings.
SDD is spray-dried drug loaded aphrons that forms a dry,
free-flowing powder.
SDD powder can be made into tablets or filled into gelatine
capsules for oral drug delivery.
The SDD delivery system is particularly suited to poorly
water-soluble drugs administered in tablet or capsule form. When
the tablet dissolves, the aphrons are released in a
water-dispersible form with the drug in solution.
The main advantage of SDD based tablets is the improved
absorption (and therefore bioavailability) of the oil soluble drug
in solution rather than its release in the form of a solid.
We have also developed a method of including liquid Polyaphron
Dispersions in capsules for oral delivery
BP is a patch encapsulating spray-dried drug loaded aphrons. The
patch is designed to adhere to the sublingual mucosa and deliver
the drug without loss into the rest of the buccal cavity. When the
matrix dissolves, the PAD reforms and efficiently delivers its drug
load through the mucosa and into the underlying blood vessels. The
patch eventually dissolves completely.