Polyaphrons are oil-in-water or water-in-oil dispersions of
colloidal dimensions that have foam like properties and related to,
yet significantly different from conventional emulsions. Individual
droplets in a Polyaphron Dispersion are called 'aphrons'.
The PAD technology requires no special ingredients and affords
unsurpassed versatility in selection of pharmaceutical grade oils,
surfactants, preservatives and other ingredients of choice. They
are manufactured in a simple procedure at room temperature using
standard equipment. Polyaphron Dispersions may be autoclaved.
The Polyaphron Dispersions are extremely stable and may contain
as much as 90% internal phase at a surfactant level of only 0.1 to
1%. Due to the low surfactant level common preservatives exhibit
relatively better efficacy in Polyaphron Dispersions.
The combination of high internal phase content and superior
stability gives rise to a number of novel and unique delivery
modalities.
The key advantages of our
Polyaphron Dispersions are summarized
below:
- Made up from wide range of pharmaceutical grade compounds and
ingredients
- Oil phase concentrations of up to 90%
- Very low surfactant levels (typically 0.1 - 1%)
- Common preservatives exhibit relatively better efficacy due to
low surfactant levels
- Inherent stability
- Allows combinations of otherwise incompatible API's
- Superior and adjustable penetration properties
- Oil soluble drugs are delivered pre-solubilized
- Opportunity to use more value adding ingredients
- Allows incorporation of high levels of silicone oils, silicone
gum, polymers and alcohol
- The rheology of the continuous phase can be tailored by a
variety of gelling agents to match the required characteristics of
feel, drag and finish
- Low cost room temperature manufacturing and cleaning using
standard equipment
- Low batch to batch variation - the oil phase and the continuous
phase are prepared separately and combined to create the final
product
- More environmentally considerate in formulation, plant
clean-up, and post-use